Perennially ageless human, John Stamos, has been cast as a regular for the second season of FOX’s comedy-horror show Scream Queens.

Scream Queens will be relocating to a hospital for its second season – last year’s debut season was set at Wallace University – and Stamos will join in the fun as a doctor. He will play Doctor Brock Holt, the hospital’s brilliant, but secretive, head surgeon. Stamos will be back wearing scrubs seven years after ER’s series finale, in which he played Doctor Tony Gates for four seasons.

This will be the third time John Stamos collaborates with Ryan Murphy, having previously guest starred on Glee and The New Normal. Stamos, whose FOX show Grandfathered was (unjustly) cancelled, will also be busy producing Fuller House and recurring as Uncle Jesse for three episodes of its second season.

During the Scream Queens’ panel at PaleyFest 2016, it was officially announced that most of last season’s cast was returning for the second season of the show. So John Stamos will join an A-list ensemble cast comprised by Jamie Lee Curtis, Emma Roberts, Lea Michele, Abigail Breslin, Keke Palmer, Billie Lourd, Glen Powell and Niecy Nash, all of whom will reprise their last season’s characters.

According to Scream Queens co-creator and producer Brad Falchuk, the second season will be inspired in the classic horror film Halloween, which made Jamie Lee Curtis famous as the original Scream Queen.

The hospital will be run by Curtis’ character, Cathy Munsch, who – according to Falchuk – “moved on to great success after abolishing the college Greek system and traveled the world in search of a new mission.”

It was also previously announced that the show would cast four actors who would be playing doctors. We are not certain if Stamos’ character is one of those four or not; regardless, we are yet to get more exciting casting news in the near future.

Once the news broke of the new characters and possible new additions to the show, Emma Roberts had this to say to E! Online: “I mean I hope there’s four hot doctors because I feel like if there is anything season two needs it’s four hot doctors. I hope they bring a couple people back from the first season cause I love all those boys so much. You are putting me on the spot, too much pressure, but I know that if Ryan Murphy does one thing well it’s casting amazing, talented and really hot people. He always casts the cutest boys!”

We agree Emma, and if John Stamos’ casting is any indication, we are sure we will be pretty happy with whoever is cast next.

Scream Queens’ season two premieres on Tuesday, September 20 at 9pm on FOX.